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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MARK1 All Species: 18.79
Human Site: S475 Identified Species: 34.44
UniProt: Q9P0L2 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9P0L2 NP_061120.3 795 89003 S475 S K S E M T A S P L V G P E R
Chimpanzee Pan troglodytes XP_001172839 796 89049 P476 K S E M T A S P L V G P E R K
Rhesus Macaque Macaca mulatta XP_001115611 778 86745 L460 P A S P L P G L E R K K T T P
Dog Lupus familis XP_536123 782 87409 S462 S K S E M T A S P L V G P E R
Cat Felis silvestris
Mouse Mus musculus Q8VHJ5 795 88528 S475 S K S E V T A S P L V G P D R
Rat Rattus norvegicus O08678 793 88216 S475 S K S E V T A S P L V G P D R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511751 793 88836 V473 G S K G E M A V S P L V G P E
Chicken Gallus gallus Q9IA88 798 88848 Q449 T I S E E V R Q E K E L E D E
Frog Xenopus laevis NP_001085126 792 88624 S475 S K G E V V A S P L A G P E R
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 S603 H L P M E R F S P V R R F S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 Q872 P P Q R A T S Q Q M S R S A T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 S203 G P E V D V W S C G V I L Y A
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E324 P D L K P H P E E E N E N N D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 68.9 95.9 N.A. 94.9 94.3 N.A. 92.8 30.4 88.6 27.8 N.A. N.A. N.A. 40.7 N.A.
Protein Similarity: 100 99.3 80.2 96.8 N.A. 97.3 96.9 N.A. 95.9 51.3 94.2 44 N.A. N.A. N.A. 51 N.A.
P-Site Identity: 100 0 6.6 100 N.A. 86.6 86.6 N.A. 6.6 13.3 73.3 13.3 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 20 13.3 100 N.A. 100 100 N.A. 13.3 26.6 80 20 N.A. N.A. N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.9 28 N.A.
Protein Similarity: N.A. N.A. N.A. 44.4 46.6 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 8 8 47 0 0 0 8 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 8 0 0 0 0 0 0 0 0 24 16 % D
% Glu: 0 0 16 47 24 0 0 8 24 8 8 8 16 24 16 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % F
% Gly: 16 0 8 8 0 0 8 0 0 8 8 39 8 0 0 % G
% His: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 8 39 8 8 0 0 0 0 0 8 8 8 0 0 8 % K
% Leu: 0 8 8 0 8 0 0 8 8 39 8 8 8 0 0 % L
% Met: 0 0 0 16 16 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 8 8 0 % N
% Pro: 24 16 8 8 8 8 8 8 47 8 0 8 39 8 8 % P
% Gln: 0 0 8 0 0 0 0 16 8 0 0 0 0 0 0 % Q
% Arg: 0 0 0 8 0 8 8 0 0 8 8 16 0 8 39 % R
% Ser: 39 16 47 0 0 0 16 54 8 0 8 0 8 8 0 % S
% Thr: 8 0 0 0 8 39 0 0 0 0 0 0 8 8 8 % T
% Val: 0 0 0 8 24 24 0 8 0 16 39 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _